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Reducing health disparity in chronic kidney disease in Zuni Indians
Investigator (PI): Shah, Vallabh
Performing Organization (PO): (Current): University of New Mexico, School of Medicine, Department of Biochemistry and Molecular Biology / (505) 272-3333
Supporting Agency (SA): Patient-Centered Outcomes Research Institute (PCORI)
Initial Year: 2013
Final Year: 2018
Record Source/Award ID: PCORI/AD-12-11-5532
Funding: Total Award Amount: $716,243
Award Type: Contract
Award Information: PCORI: More information and project results (when completed)
Abstract: People reach end-stage renal disease (ESRD) due to progressive chronic kidney disease (CKD). CKD is associated with increased risks for heart disease and death. The burden of CKD is increased among minority populations compared to Caucasians. The Zuni Indians are experiencing an epidemic of CKD due primarily to the high rates of obesity and diabetes. The present study, titled Home-Based Kidney Care, is designed to delay/reduce rates of ESRD and cost associated with dialysis by early interventions in CKD. We propose to assess the safety and efficacy of conducting a full-scale study to determine if home-based care delivered by a collaborative team composed of community health workers and University of New Mexico faculty will decrease the risk for the development and the progression of CKD. More on this project: (1) A.A. Shah, C.K. Zogg, S.N. Zafar et al., Analgesic Access for Acute Abdominal Pain in the Emergency Department Among Racial/Ethnic Minority Patients: A Nationwide Examination. Medical Care 53(12) (December 2015): 1000-1009. (2) Shah VO, Carroll C, Mals R, Ghahate D, Bobelu J, Sandy P, Colleran K, Schrader R, Faber T, Burge MR. A Home-Based Educational Intervention Improves Patient Activation Measures and Diabetes Health Indicators among Zuni Indians. PLoS One. 2015 May 8;10(5):e0125820. doi: 10.1371/journal.pone.0125820. eCollection 2015. PubMed PMID: 25954817; PubMed Central PMCID: PMC4425648. (3) Laston SL, Voruganti VS, Haack K, Shah VO, Bobelu A, Bobelu J, Ghahate D, Harford AM, Paine SS, Tentori F, Cole SA, MacCluer JW, Comuzzie AG, Zager PG. Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project. Front Genet. 2015 Jan 30;6:6. doi: 10.3389/fgene.2015.00006. eCollection 2015. PubMed PMID: 25688259; PubMed Central PMCID: PMC4311707. (4) Newman S, Cheng T, Ghahate DM, Bobelu J, Sandy P, Faber T, Shah VO. Assessing knowledge and attitudes of diabetes in Zuni Indians using a culture-centered approach. PLoS One. 2014 Jun 11;9(6):e99614. doi: 10.1371/journal.pone.0099614. eCollection 2014. PubMed PMID: 24919064; PubMed Central PMCID: PMC4053347. (5) Shah VO, Ghahate DM, Bobelu J, Sandy P, Newman S, Helitzer DL, Faber T, Zager P. Identifying barriers to healthcare to reduce health disparity in Zuni Indians using focus group conducted by community health workers. Clin Transl Sci. 2014 Feb;7(1):6-11. doi: 10.1111/cts.12127. PubMed PMID: 24528897; PubMed Central PMCID: PMC3929233. (6) Thameem F, Igo RP Jr, Freedman BI, Langefeld C, Hanson RL, Schelling JR, Elston RC, Duggirala R, Nicholas SB, Goddard KA, Divers J, Guo X, Ipp E, Kimmel PL, Meoni LA, Shah VO, Smith MW, Winkler CA, Zager PG, Knowler WC, Nelson RG, Pahl MV, Parekh RS, Kao WH, Rasooly RS, Adler SG, Abboud HE, Iyengar SK, Sedor JR; Family Investigation of Nephropathy and Diabetes Research Group. A genome-wide search for linkage of estimated glomerular filtration rate (eGFR) in the Family Investigation of Nephropathy and Diabetes (FIND). PLoS One. 2013 Dec 17;8(12):e81888. doi: 10.1371/journal.pone.0081888. eCollection 2013. PubMed PMID: 24358131; PubMed Central PMCID: PMC3866106. (7) Shah VO, Townsend RR, Feldman HI, Pappan KL, Kensicki E, Vander Jagt DL. Plasma metabolomic profiles in different stages of CKD. Clin J Am Soc Nephrol. 2013 Mar;8(3):363-70. doi: 10.2215/CJN.05540512. PubMed PMID: 23220422; PubMed Central PMCID: PMC3586968. (8) Home-based Care for Chronic Kidney Disease--A narrative on how kidney disease is rampant among Zuni Indians and researchers test a novel home-based care model to combat the epidemic. https://www.pcori.org/research-in-action/home-based-care-chronic-kidney-disease (9) Video: Vallabh O. Shah talks about the impact of including key community members for his project. https://www.youtube.com/watch?v=2LGiiip4PBg
MeSH Terms:
  • Community Health Workers
  • Diabetes Mellitus /ethnology
  • Disease Progression
  • Health Care Costs
  • Health Services Accessibility
  • * Health Status Disparities
  • * Healthcare Disparities
  • Home Care Services /*organization & administration
  • Humans
  • Indians, North American
  • Kidney Failure, Chronic /*ethnology
  • /*prevention & control
  • New Mexico
  • Obesity /complications
  • /ethnology
  • Patient Care Team
  • Renal Insufficiency, Chronic /ethnology
  • /therapy
  • Risk
  • Universities
Country: United States
State: New Mexico
Zip Code: 87131
UI: 20143244
CTgovId: NCT02081846
Project Status: Completed
Record History: ('2017: Project extended to 2018.',)