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Physical therapy vs. internet-based exercise training for patients with knee osteoarthritis
Investigator (PI): Allen, Kelli D
Performing Organization (PO): (Current): Duke University, School of Medicine, Department of Medicine, Division of General Internal Medicine / (919) 668-0300
Supporting Agency (SA): Patient-Centered Outcomes Research Institute (PCORI)
Initial Year: 2014
Final Year: 2018
Record Source/Award ID: PCORI/CER-1306-02043
Funding: Total Award Amount: $1,949,199
Award Type: Contract
Award Information: PCORI: More information and project results (when completed)
Abstract: Objectives: This project will compare standard physical therapy (PT) with an internet-based exercise training program (IBET) for patients with knee osteoarthritis (OA). Both of these programs will be compared to a wait list control group (WL) that receives a program after their study assessments are complete. The project will also evaluate patient characteristics that may be associated with different levels of improvement in PT or IBET. Methods: This will be a randomized controlled trial of n=350 patients with symptomatic knee OA. Patients will be enrolled from primary care clinics that serve high proportions of uninsured individuals and those in areas with little access to physical therapists. The PT arm will consist of 3-8 visits, which is comparable to standard PT for knee OA in clinical settings. The IBET program simulates exercise prescription as it occurs in rehabilitation settings. This interactive program uses patient-specific information to tailor an initial exercise program and provide ongoing monitoring, re-evaluation, and re-prescription. The system also provides videos of all exercises to help participants perform them correctly. Participants will have access to the IBET program for the duration of the study period. Patient outcomes: Outcomes will be assessed at baseline, 4 months, and 12 months. The primary outcome will be the Western Ontario and McMasters Universities Osteoarthritis Index, a measure of lower extremity pain, stiffness and function. Secondary outcomes will include physical activity level, satisfaction with function, depressive symptoms, health-related quality of life, and patient global assessment of change. Appropriate statistical models will be used to compare outcomes across the three groups at each study time point. Other statistical analyses will be used to evaluate whether specific patient characteristics are associated with differences in treatment response in either intervention group. We will also obtain patient feedback on the interventions. More on this project: Quinn I. Williams, Alexander H. Gunn, John E. Beaulieu et al., "Physical Therapy vs. Internet-Based Exercise Training (PATH-IN) for Patients with Knee Osteoarthritis: Study Protocol of a Randomized Controlled Trial," BMC Musculoskeletal Disorders. 2015 Sep 28;16:264. doi: 10.1186/s12891-015-0725-9.
MeSH Terms:
  • * Exercise
  • Exercise Therapy /*methods
  • Health Services Accessibility
  • Humans
  • * Internet
  • Medically Uninsured
  • Models, Statistical
  • Osteoarthritis, Knee /*therapy
  • Outcome Assessment, Health Care
  • * Physical Therapy Modalities
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Severity of Illness Index
Country: United States
State: North Carolina
Zip Code: 27705
UI: 20143542
CTgovId: NCT02312713
Project Status: Completed
Record History: ('2017: Project extended to 2018',)