National Information Center on Health Services Research and Health Care Technology (NICHSR)
HSRProj (Health Services Research Projects in Progress)
Information about ongoing health services research and public health projects
| Propensity score-based methods for comparative effectiveness research (CER) using multilevel data: what works best when | |
|---|---|
| Investigator (PI): | Kim, Mi Ok |
| Performing Organization (PO): |
(Current): University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center / (877) 827-3222 (Past): Cincinnati Children's Hospital Medical Center / (513) 636-4200 |
| Supporting Agency (SA): | Patient-Centered Outcomes Research Institute (PCORI) |
| Initial Year: | 2015 |
| Final Year: | 2019 |
| Record Source/Award ID: | PCORI/ME-1403-13922-IC ; PCORI/ME-1403-13922 |
| Funding: | Total Award Amount: $652,777 |
| Award Type: | Contract |
| Award Information: | PCORI: More information and project results (when completed) |
| Abstract: | The decision to adopt a treatment is complex, and the doctor, patient, and parents/guardians interact and consider a number of factors. Some of these factors may predict better or worse patient outcomes regardless of whether the treatment is effective. This problem is known as confounding. Confounding, when present, may complicate explaining the relationship between the outcome and the treatment as other factors may be responsible for the relationship. Confounding is often present when treatments are selected rather than randomly assigned. Thus confounding, unless properly addressed, may render the results of a study invalid or even irrelevant. The proper treatment of confounding gets more complex for studies where patients are clustered, for example, by geographical area of residence, health care provider (hospital/clinic or physician), or health plan. This study will focus on how to properly address confounding in this complex situation. The proper treatment consists of two parts, first accounting for its effect in relating the observed outcome to the treatment as best as one can by using available data, and second examining how easily or dramatically the outcome relationship with the treatment changes if confounding is not sufficiently well addressed with the available data. We will develop novel approaches for both parts. To facilitate the development of the methodologies, we will use both computer simulated data and real data examples. The two complement each other for comprehensively evaluating the novel approaches developed in this study. The complex situation with confounding occurs commonly in studies using registries, network databases or electronic health record (EHR) databases. The Patient-Centered Outcomes Research Institute specifically launched a new initiative of forming national patient-centered clinical research network (PCORnet) to facilitate comparative effectiveness research (CER). It currently funds 29 individual data networks (18 PPRNs and 11 CDRNs). CER studies using this PCORnet will face a complex situation. This study will contribute significantly to the PCORI's mission. More on this project: E. Nehus, C. Liu, D.K. Hooper et al. Clinical Practice of Steroid Avoidance in Pediatric Kidney Transplantation. American Journal of Transplantation 15(8) (August 2015): 2203-2210. |
| MeSH Terms: |
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| Country: | United States || United States |
| State: | California || Ohio |
| Zip Code: | 45229 / 94143 |
| UI: | 20152319 |
| Project Status: | Completed |
| Record History: | ('2019: Project extended to 2019 ',) ('2017: Project extended to 2018',) ('2018: PO changed',) |