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University of Washington Urinary Stone Disease Research Network (USDRN) Clinical Center (UWCC)
Investigator (PI): Harper, Jonathan D; Wessells, Hunter
Performing Organization (PO): (Current): University of Washington, School of Medicine, Department of Urology / (206) 543-3640
Supporting Agency (SA): National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Initial Year: 2016
Final Year: 2021
Record Source/Award ID: RePorter/U01DK110954
Funding: 2016 Award Amount: $681,625
Award Type: Grant
Abstract: The University of Washington Urinary Stone Disease Clinical Center (UWCC) seeks to advance the field of urinary stone disease (USD) research through participation in the Research Network and by taking a comprehensive aim at the problem of ureteral stent burden. In the United States, USD affects 1 in 9 adults, exerting a substantial burden related to pain, lost work, and health care expenditures that add up to $10 billion per year. The per capita disability from USD in the United States is higher than any other nation, potentially reflecting the cost and side effects of intensive treatment. A team of investigators with broad experience in urology, pediatrics, nephrology, health services, bioinformatics, pharmacogenetics, pain medicine, and biostatistics across the University of Washington, Seattle Children's Hospital and the VA Puget Sound Health Care System will address this complex problem, harnessing the extensive patient care and research infrastructure of these institutions. The clinical activity of 6 hospitals will be harnessed to provide the platform for sufficient sample sizes to address two main facets of USD. Our specific aims include (1) to determine the effectiveness of a short message service (SMS, or text) reminder-optimized, fluid-intake intervention on kidney stone recurrence in urinary stone formers; (2) to characterize the symptom burden of ureteral stents and to evaluate strategies that reduce ureteral stent-related pain and discomfort; and (3) to identify novel mechanistic candidates associated with stent-related pain and urinary bother. Our interrelated aims set the stage for future USDRN-wide trials to move top study designs and tools into translational applications, including those for disease prevention, drug targeting of severe stent-related problems, and biomarker development. We envision that our proposed strategies will move USD prevention and treatment beyond a trial-and-error approach, informing clinically relevant intervention and prevention decisions at both an individual and a population level.
MeSH Terms:
  • Clinical Trials as Topic
  • Comparative Effectiveness Research
  • Disabled Persons
  • Health Services Research
  • Hospitals, Pediatric
  • Hospitals, Veterans
  • Humans
  • Interdisciplinary Communication
  • Multicenter Studies as Topic
  • Nephrology /methods
    • /*organization & administration
  • Recurrence
  • Reminder Systems
  • Research Design
  • Sample Size
  • Stents
  • Text Messaging
  • Translational Medical Research
  • United States
  • United States Department of Veterans Affairs
  • Universities
  • Ureter /surgery
  • Urinary Calculi /prevention & control
    • /*therapy
  • Washington
Keywords:
  • United States
  • Washington
  • adult
  • child
  • childhood
  • clinical
  • disease management
  • effectiveness
  • hospitals
  • inflammation
  • intervention
  • kidney calculi
  • liquid substance
  • mobile computing
  • pain
  • pain symptom
  • participant
  • pediatric hospitals
  • pediatrics
  • physicians
  • recurrence
  • stents
  • symptoms
  • text
  • urinary
  • urinary calculi
  • urology
  • veterans
Country: United States
State: Washington
Zip Code: 98195
UI: 20173273
Project Status: Ongoing