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Comparison of treatment efficacy for prostate cancer.
(Archived Project)
Investigator (PI): Albertsen, Peter C
Performing Organization (PO): (Current): University of Connecticut Health Center
Supporting Agency (SA): Agency for Healthcare Research and Quality (AHRQ)
Initial Year: 1998
Final Year: 2003
Record Source/Award ID: CRISP/R01HS09578
Award Type: Grant
Abstract: This is a prospective cohort study of men diagnosed during the early 1990's with prostate carcinoma in the state of Connecticut. The study is primarily descriptive using the Connecticut tumor registry. The investigators propose to determine frequencies and timing of secondary cancer therapies among men treated in this community-cohort. They will also determine the frequency and timing of PSA elevation as a reflection of an increasing tumor burden. Ten year cause-specific and all-cause mortality will be determined. Initial tumor histology slides will be retrieved and reviewed by an experienced pathologist. Specific questions to be addressed will include: outcomes among specific treatment groups including surgery, radiation or conservative treatment. These will be stratified by controlling for age, race, pre-treatment PSA, surgical stage and commodity. Other questions include the risk of receiving secondary cancer therapy controlling for these initial issues. Finally, they will determine the ability of demographic, co-morbidity, histologic grade, and pre-treatment PSA to predict disease progression and mortality.
MeSH Terms:
  • Carcinoma /mortality
  • /pathology /*therapy
  • Cause of Death /*trends
  • Cohort Studies
  • Connecticut
  • Demography
  • Disease Progression
  • General Surgery
  • Humans
  • Male
  • Prognosis
  • Prospective Studies
  • Prostate-Specific Antigen /*analysis
  • Prostatic Neoplasms /mortality
  • /pathology /*therapy
  • Radiotherapy
  • Registries
  • Treatment Outcome
Keywords:
  • research support, non-U.S. Gov't
Country: United States
State: Connecticut
Zip Code: 06030
UI: 98300050
Project Status: Archived